Applying solitary-molecule optical and AFM imaging and force-spectroscopy methods, we seek to unravel the mechanistic components of the framework and dynamics of chromosomes. Our study pursuits include things like:
Human Rad51 filaments on double- and one-stranded DNA: correlating normal and irregular varieties with recombination function.
[Laughs] ‘It was certainly a terrific chance! At enough time, I used to be effectively conscious that it could go Improper and that I could become significantly less successful, but I just disregarded that. Curiosity has generally been my strongest driving pressure. And fortuitously it all worked out.’
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
This yielded a breakthrough. Inside only some months, we have been able to evaluate transportation by way of an individual solitary-walled carbon nanotube. Based on very low-temperature experiments by a brilliant PhD scholar in my group, Sander Tans (now a valued colleague and professor at Delft College of Technology using an active investigation lab at AMOLF in Amsterdam), we showed that carbon nanotubes have been legitimate quantum wires with really extensive (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic conduct.
Experimental phase diagram of negatively supercoiled DNA calculated by magnetic tweezers and fluorescence,
MATLAB codes for knowledge processing are available at . Julia codes useful for numerical simulation can be found at .
2000, discovery that nanotubes can carry amazing significant existing densities; solved the controversial issue of electronic transportation as a result of DNA molecules by measurements of insulating conduct at The one molecule amount; and demonstration of an AFM strategy for one-molecule manipulation of nanotubes
In 1993, being a youthful and keen affiliate professor at Delft University of Engineering, I'd originally targeted the investigation endeavours of my team on measuring the electrical conductance of a single conducting-polymer molecule. In two yrs, we experienced created a device during which one wire of the phthalocyaninepolysiloxane polymer was related between two closely spaced metal nanoelectrodes.
But carbon nanotubes have remained a study topic of considerable interest to many. In truth, the outlook on applying carbon nanotubes to make realistic products, in regions including radio-frequency electronics, digital electronics and versatile electronics, continues to be vivid.
‘The idea that There exists this kind of detail as a beginning, a huge bang, is by now a fascinating signpost to think about that there was a creator. But a lot more normally, and on The idea of pure rationality, I also get there in a Christian interpretation of fact. An atheistic worldview is often a naturalistic worldview: essentially, there are only atoms and all-natural forces that cees dekker we are able to measure.
2006, 1st demonstration of molecular sorting inside of a lab on a chip employing biomotors; discovery of nanobubbles in good-state nanopores; and initial estimate of electrokinetic Electricity conversion inside of a nanofluidic channel
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of only one wire bridging two electrodes
The biophysicist from Delft – who has actually been Among the most cited researchers within the Netherlands For a long time – requires his responsibility to add on the explanation and popularisation of his work within the border of physics and biology particularly significantly and routinely seems while in the media; if not to take a look at his get the job done, then about the relationship between science and his Christian religion.